Abstract
A series of trans-fused lactams containing the indane nucleus has been prepared. Compound 19 has much enhanced plasma stability compared with its lactone counterpart and shows appreciable in vitro anticoagulant activity.
MeSH terms
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Anticoagulants / chemical synthesis
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Anticoagulants / pharmacology*
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Binding Sites
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / pharmacology
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Indans / chemical synthesis
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Indans / pharmacology*
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Inhibitory Concentration 50
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Lactams / chemical synthesis
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Lactams / pharmacology*
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Models, Molecular
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Structure-Activity Relationship
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Thrombin / antagonists & inhibitors*
Substances
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Anticoagulants
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Enzyme Inhibitors
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Indans
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Lactams
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Thrombin